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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G/A
Under the Securities Exchange Act of 1934
(Amendment No. 2)*
Alexion Pharmaceuticals, Inc.
-------------------------------------------
(Name of Issuer)
Common Stock, ($.0001 par value)
-------------------------------------------
(Title of Class of Securities)
015351109
------------------------
(CUSIP Number)
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 2 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | BIOTECHNOLOGY INVESTMENT GROUP, LLC ("BIO") |
| | 06-141 5704 |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | -0- |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 647,575 |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | -0- |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 647,575 |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 647,575 |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 6.8% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | 00 |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 3 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | EDWARD BLECH TRUST ("EBT") |
| | 25-638 1634 |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | New York |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | -0- |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 647,575 |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | -0- |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | -0- |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 647,575 |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 6.8% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | 00 |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 4 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | COLLINSON HOWE VENTURE PARTNERS, INC. |
| | 13-354 8019 |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | -0- |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 676,439 |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | -0- |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 676,439 |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 676,439 |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 7.1% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | CO |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 5 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | SCHRODERS INCORPORATED ("SI") |
| | 13-262 1402 |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | -0- |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 28,864 |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | -0- |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 28,864 |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 28,864 |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | .03% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | CO |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 6 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | JEFFREY J. COLLINSON ("JJC") |
| | N/A |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | U.S.A. |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | 3,497 |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | 676,439 |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | 3,497 |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | 676,439 |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | 679,936 |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 7.1% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | IN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 7 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | SCHRODER VENTURES U.S. TRUST ("SVUST") |
| | 13-691 3552 |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Bermuda |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | -0- |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | -0- |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | -0- |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | -0- |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | -0- |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 0% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | 00 |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 8 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
|--------|---------------------------------------------------------------------|
| 1 | NAME OF REPORTING PERSON |
| | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
| | SCHRODER VENTURES LIMITED PARTNERSHIP ("SVLP") |
| | 13-348 4238 |
|--------|---------------------------------------------------------------------|
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] |
| | (b) [ ] |
| | |
|--------|---------------------------------------------------------------------|
| 3 | SEC USE ONLY |
| | |
|--------|---------------------------------------------------------------------|
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION |
| | |
| | Delaware |
|-----------------|--------|---------------------------------------------------|
| | 5 | SOLE VOTING POWER |
| | | -0- |
| NUMBER OF |--------|---------------------------------------------------|
| SHARES | 6 | SHARED VOTING POWER |
| BENEFICIALLY | | -0- |
| OWNED BY |--------|---------------------------------------------------|
| EACH | 7 | SOLE DISPOSITIVE POWER |
| REPORTING | | -0- |
| PERSON |--------|---------------------------------------------------|
| WITH | 8 | SHARED DISPOSITIVE POWER |
| | | -0- |
|------------------------------------------------------------------------------|
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| | |
| | -0- |
|--------|---------------------------------------------------------------------|
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN [ ] |
| | SHARES* |
| | |
|--------|---------------------------------------------------------------------|
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| | 0% |
|--------|---------------------------------------------------------------------|
| 12 | TYPE OF REPORTING PERSON* |
| | PN |
- --------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 9 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
Item 1(a). Name of Issuer: Alexion Pharmaceuticals, Inc.
Item 1(b). Address of Issuer's Principal Executive Offices:
25 Science Park
New Haven, CT 06511
Item 2. Names, Addresses and Citizenship of Persons Filing:
---------------------------------------------------
I. For Reporting Person
--------------------
Biotechnology Investment Group, L.L.C.:
a) Biotechnology Investment Group, L.L.C.
b) c/o Collinson Howe Venture Partners, Inc.
1055 Washington Boulevard
Stamford, CT 06901
c) Place of organization -- Delaware
II. Regarding Reporting Person Edward Blech Trust:
a) Edward Blech Trust
b) 418 Avenue I
Brooklyn, NY 11231
c) Trusted created under laws of New York
Regarding Reporting Person Collinson Howe Venture Partners, Inc.
a) Collinson Howe Venture Partners, Inc.
b) 1055 Washington Boulevard
Stamford, CT 06901
c) Place of Organization - Delaware
Regarding Reporting Person Schroders Incorporated
a) Schroders Incorporated
b) 787 Seventh Avenue, 29th Floor
New York, NY 10019
c) Place of Organization -- Delaware
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 10 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
Regarding Reporting Person Jeffrey J. Collinson:
a) Jeffrey J. Collinson
b) 1055 Washington Boulevard,
Stamford, CT 06901
c) Citizenship - United States
Regarding Reporting Person Schroder Ventures US Trust:
a) Schroder Ventures U.S. Trust
b) c/o Schroder Venture Managers Limited
22 Church Street
Hamilton HM 11, Bermuda
c) SVUST is a closed-end unit trust created under the laws of
Bermuda
Regarding Reporting Person Schroder Ventures Limited Partnership:
a) Schroder Ventures Limited Partnership
b) c/o Schroder Ventures Management L.P.
787 Seventh Avenue
29th Floor
New York, NY 10019
c) Place of organization -- Delaware
Item 2(d). Title of Class of Securities: Common Stock
Item 2(e). CUSIP Number: 015351109
Item 3. If this statement if filed pursuant to Rules 13d-1(b), or
---------------------------------------------------------
13d-2(b), check whether the person filing is a:
-----------------------------------------------
(a) [ ] Broker or Dealer registered under
Section 15 of the Securities Exchange Act of
1934 (the "Act"),
(b) [ ] Bank as defined in Section 3(a)(6) of the Act,
(c) [ ] Insurance Company as defined in Section 3(a)(19)
of the Act,
(d) [ ] Investment Company registered under Section 8 of
the Investment Company Act of 1940,
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 11 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
(e) [ ] Investment Advisor registered under
Section 203 of the Investment Advisers Act
of 1940,
(f) [ ] Employee Benefit Plan, Pension Fund
which is subject to the provisions of the
Employee Retirement Income Security Act of
1974 or Endowment Fund; see
Rule 13d-1(b)(1)(ii)(f) of the Act,
(g) [ ] Parent Holding Company, in accordance
with Rule 13d-1(b)(ii)(G) of the Act;
see Item 7,
(h) [ ] Group, in accordance with Rule
13d-1(b)(1)(ii)(H) of the Act.
Not Applicable.
Item 4. Ownership.
----------
See Items 5-8 on cover pages.
Item 5. Ownership of Five Percent or Less of a Class.
---------------------------------------------
This statement is being filed to report the fact that as of
the date hereof, the following reporting persons have ceased
to be the beneficial owners of more than five percent of the
class of securities:
Schroders Incorporated
Schroder Ventures U.S. Trust
Schroder Ventures Limited Partnership
Item 6. Ownership of More than Five Percent on Behalf of Another
--------------------------------------------------------
Person.
-------
Not Applicable.
Item 7. Identification and Classification of the Subsidiary which
---------------------------------------------------------
Acquired the Security Being Reported on By the Parent Holding
-------------------------------------------------------------
Company.
--------
Not Applicable.
Item 8. Identification and Classification of Members of the Group.
----------------------------------------------------------
Not applicable.
Item 9. Notice of Dissolution of Group.
-------------------------------
Not Applicable.
Item 10. Certification.
--------------
Not Applicable. This statement on Schedule 13G is not filed
pursuant to Rule 13d-1(b).
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 12 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
Signature
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
February 14, 1998 BIOTECHNOLOGY INVESTMENT GROUP, L.L.C.
----------------- By: COLLINSON HOWE VENTURE PARTNERS, INC.
Date Its: Managing Member
By: *
------------------------------------
Jeffrey J. Collinson, President
EDWARD BLECH TRUST
By: *
------------------------------------
Mordechai Jofen, as Sole Trustee
COLLINSON HOWE VENTURE PARTNERS, INC.
By: *
------------------------------------
Jeffrey J. Collinson, President
*
-----------------------------------------
Jeffrey J. Collinson
SCHRODERS INCORPORATED
By: *
------------------------------------
Jeffrey J. Collinson,
Its Attorney-in-Fact
SCHRODER VENTURES U.S. TRUST
By: SCHRODER VENTURE MANAGERS LIMITED
Its: Manager
By: *
------------------------------------
- ------------------------- ---------------------------
|CUSIP NO. 015351109 | 13G | Page 13 of 13 Pages |
| --------- | | --- --- |
- ------------------------- ---------------------------
SCHRODER VENTURES LIMITED
PARTNERSHIP
By: SCHRODER VENTURES MANAGEMENT L.P.
Its: General Partner
By: SCHRODER VENTURE MANAGERS INC.
Its: General Partner
By: *
----------------------------------------
* By: ______________________________________
Timothy C. Maguire, Attorney-in-Fact