Registration No. 333- As filed with the Securities and Exchange Commission on November 19, 1999 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ------------------------ FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ------------------------ ALEXION PHARMACEUTICALS, INC. (Exact name of Registrant as specified in its charter) DELAWARE 13-3648318 (State or other jurisdiction of (I.R.S. Employer incorporation or organization) Identification No.) ------------------------ 25 SCIENCE PARK NEW HAVEN, CT 06511 (203) 498-4210 (Address, including zip code, and telephone number, including area code, of Registrant's principal executive offices) ------------------------------ LEONARD BELL, M.D. ALEXION PHARMACEUTICALS, INC. 25 SCIENCE PARK NEW HAVEN, CT 06511 (203) 776-1790 (Name, address, including zip code, and telephone number, including area code, of agent for service) ------------------------------ with copies to: MERRILL M. KRAINES, ESQ. DAVID R. KING, ESQ. LAWRENCE A. SPECTOR, ESQ. MICHAEL J. SHIM, ESQ. FULBRIGHT & JAWORSKI L.L.P. MORGAN, LEWIS & BOCKIUS LLP 666 FIFTH AVENUE 1701 MARKET STREET NEW YORK, NEW YORK 10103 PHILADELPHIA, PENNSYLVANIA 19103 (212) 318-3000 (215) 963-5000 ------------------------ APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as practicable after the effective date of this Registration Statement. If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box: [ ] If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [X] 333-89343 If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration number of the earlier effective registration statement for the same offering. [ ] If delivery of the prospectus is expected to be made pursuant to Rule 434, please check the following box. [X] CALCULATION OF REGISTRATION FEE PROPOSED PROPOSED MAXIMUM TITLE OF EACH CLASS OF SECURITIES AMOUNT TO BE MAXIMUM OFFERING AGGREGATE AMOUNT OF TO BE REGISTERED REGISTERED(1) PRICE PER SHARE OFFERING PRICE(1) FEE Common Stock, $.0001 par value 540,000 shares $14.00 $7,560,000 $2,102.00 (1) Includes 40,000 shares of Common Stock which the Underwriters have the option to purchase to cover over-allotments, if any. ------------------------------ THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THE REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A), MAY DETERMINE.
INCORPORATION BY REFERENCE OF REGISTRATION STATEMENT ON FORM S-3, FILE NO. 333-89343 Alexion Pharmaceuticals, Inc. (the "Company") hereby incorporates by reference into this Registration Statement on Form S-3 in its entirety the Registration Statement on Form S-3 (File No. 333-89343) declared effective on November 19, 1999 by the Securities and Exchange Commission (the "Commission"), including each of the documents filed by the Company with the Commission and incorporated or deemed to be incorporated by reference therein. 2
ITEM 16. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES. (a) Exhibits. 5.1 Opinion of Fulbright & Jaworski L.L.P. 23.1 Consent of Arthur Andersen LLP. 23.2 Consent of Fulbright & Jaworski L.L.P. (contained in Exhibit 5.1). 24.1 Power of Attorney (included on signature page).
SIGNATURES PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, AS AMENDED, THE REGISTRANT HAS DULY CAUSED THIS REGISTRATION STATEMENT TO BE SIGNED ON ITS BEHALF BY THE UNDERSIGNED, THEREUNTO DULY AUTHORIZED, IN THE CITY OF NEW HAVEN AND STATE OF CONNECTICUT ON THE 19TH DAY OF NOVEMBER, 1999. ALEXION PHARMACEUTICALS, INC. By: /s/ LEONARD BELL ----------------------------------------- Leonard Bell, M.D. PRESIDENT, CHIEF EXECUTIVE OFFICER, SECRETARY AND TREASURER POWER OF ATTORNEY KNOW ALL MEN BY THESE PRESENTS, that each individual whose signature appears below constitutes and appoints LEONARD BELL, M.D. and DAVID W. KEISER, or either of them, his true and lawful attorney-in-fact and agent with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same with all exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission, granting said attorney-in-fact and agent, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent or any of them, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated: President, Chief Executive /s/ LEONARD BELL Officer, Secretary, ------------------------------------------- Treasurer and Director November 19, 1999 Leonard Bell, M.D. (principal executive officer) Executive Vice President /s/ DAVID W. KEISER and Chief Operating ------------------------------------------- Officer (principal November 19, 1999 David W. Keiser financial officer) Vice President of Finance /s/ BARRY P. LUKE and Administration ------------------------------------------- (principal accounting November 19, 1999 Barry P. Luke officer) /s/ JOHN H. FRIED ------------------------------------------- Chairman of the Board of November 19, 1999 John H. Fried, Ph.D. Directors II-4
------------------------------------------- Director November 19, 1999 Jerry T. Jackson /s/ JOSEPH A. MADRI ------------------------------------------- Director November 19, 1999 Joseph A. Madri, Ph.D., M.D. /s/ LEONARD MARKS, JR. ------------------------------------------- Director November 19, 1999 Leonard Marks, Jr., Ph.D. /s/ MAX LINK ------------------------------------------- Director November 19, 1999 Max Link, Ph.D. /s/ EILEEN M. MORE ------------------------------------------- Director November 19, 1999 Eileen M. More ------------------------------------------- Director November 19, 1999 R. Douglas Norby ------------------------------------------- Director November 19, 1999 Alvin S. Parven II-5
Exhibit 5.1 HOUSTON FULBRIGHT & JAWORSKI L.L.P. WASHINGTON, D.C. TELEPHONE: 212/318-3000 A REGISTERED LIMITED LIABILITY AUSTIN FACSIMILE: 212/752-5958 PARTNERSHIP SAN ANTONIO 666 FIFTH AVENUE DALLAS NEW YORK, NEW YORK 10103 NEW YORK LOS ANGELES LONDON HONG KONG November 19, 1999 Alexion Pharmaceuticals, Inc. 25 Science Park New Haven, Connecticut 06511 Ladies and Gentlemen: We have acted as counsel to Alexion Pharmaceuticals, Inc., a Delaware corporation (the "Company"), in connection with its filing with the Securities and Exchange Commission of a Registration Statement on Form S-3 (the "Abbreviated Registration Statement"), under the Securities Act of 1933, as amended (the "Act") for the registration of 500,000 shares of common stock, par value $.0001 per share, of the Company (the "Common Stock") and up to an additional 40,000 shares of Common Stock subject to an option (the "Over-Allotment Option") from the Company to the underwriters, exercisable within thirty (30) days after the effective date of the Registration Statement, to cover over-allotments. The Abbreviated Registration Statement relates to the same class of securities registered pursuant to the Company's Registration Statement on Form S-3 (No. 333-89343) declared effective earlier today (the "Initial Registration Statement"). The Abbreviated Registration Statement, together with the Initial Registration Statement (collectively, the "Registration Statement"), relate to the proposed sale by the Company in a public offering of an aggregate of 2,500,000 shares of the Company's Common Stock. The Registration Statement also relates to the proposed sale by the Company of an aggregate of up to an additional 375,000 shares of Common Stock subject to the Over-Allotment Option. All such shares of Common Stock are hereinafter referred to as the "Shares." In connection with this opinion, we, as counsel for the Company, have examined such corporate records, other documents and questions of law as we have considered necessary or appropriate for the purposes of this opinion. Our opinion set forth below is limited to the General Corporation Law of the State of Delaware. We assume that appropriate action will be taken, prior to the offer and sale of the Shares, to register and qualify the Shares for sale under all applicable state securities or "blue sky" laws. In our examination of the foregoing documents, we have assumed the genuineness of all signatures and the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as certified or photostatic copies, and the authenticity of the originals of such latter documents. Based on and subject to the foregoing, we advise you that in our opinion, the Shares to be sold by the Company have been duly and validly authorized and, when issued and sold in the manner contemplated by the
November 19, 1999 Page 2 Purchase Agreement, a form of which has been filed as an exhibit to the Registration Statement (the "Purchase Agreement"), and upon receipt by the Company of payment therefor as provided in the Purchase Agreement, will be duly and validly authorized, legally issued, fully paid and non-assessable. We hereby consent to the filing of this opinion as an exhibit to the Registration Statement and the reference to this firm under the caption "Legal Matters" in the prospectus contained therein. This consent is not to be construed as an admission that we are a party whose consent is required to be filed with the Registration Statement under the provisions of the Act or the rules and regulations of the Securities and Exchange Commission promulgated thereunder. The opinion expressed herein is solely for your benefit, and may be relied upon only by you. Very truly yours, /s/ Fulbright & Jaworski L.L.P.
EXHIBIT 23.1 CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS As independent public accountants, we hereby consent to the incorporation by reference in this registration statement of our report dated August 27, 1999 included in Alexion Pharmaceuticals, Inc.'s Form 10-K for the year ended July 31, 1999 and to all references to our Firm included in this registration statement. /s/ ARTHUR ANDERSEN LLP Hartford, Connecticut November 16, 1999