UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

- --------------------------------------------------------------------------------

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                                (Amendment No. 1)


                          ALEXION PHARMACEUTICALS, INC.
                                (Name of Issuer)

                                  Common Stock
                         (Title of Class of Securities)

                                    015351109
                                 (CUSIP Number)



















- --------------------------------------------------------------------------------
Check the following box if a
fee is being paid with this statement.  |_|








                                        2

CUSIP No.  015351109

(1)          Name of Reporting Person
             S.S. or I.R.S. Identification No. of Above Person
                Citibank, N.A.; 13-5266470                      
             -------------------------------------------------------------------

(2)          Check the Appropriate Box if a Member of Group (See Instructions)

|_|          (a)
                 ---------------------------------------------------------------

|_|          (b)
                 ---------------------------------------------------------------

(3)          SEC Use Only
                          ------------------------------------------------------
             -------------------------------------------------------------------

(4)          Citizenship or Place of Organization  New York                  
                                                   -----------------------------

                (5)      Sole Voting Power  0                                
Number of                                  -------------------------------------
Shares                   -------------------------------------------------------
Beneficially    (6)      Shared Voting Power 417,575                         
Owned by                                     -----------------------------------
Each                     -------------------------------------------------------
Reporting                -------------------------------------------------------
Person                      (7)      Sole Dispositive Power  0               
With                                            --------------------------------
                         -------------------------------------------------------
- -------------   (8)      Shared Dispositive Power 417,575                    
                                                  ------------------------------

(9)          Aggregate Amount Beneficially Owned by Each Reporting Person
                                                                         417,575
                                                                         -------

(10)         Check if the Aggregate Amount in Row (9) Excludes Certain Shares 
             (See Instructions)
             -------------------------------------------------------------------
             -------------------------------------------------------------------

(11)         Percent of Class Represented by Amount in Row (9)
             3.7%
             -------------------------------------------------------------------

(12)         Type of Reporting Person (See Instructions) BK*
                                                        ---- 
- --------

*    The reporting person is a pledgee with limited voting and dispositive power
pursuant to certain voting trust agreements. The reporting person disclaims
beneficial ownership of these securities, and this report shall not be deemed an
admission that the reporting person is the beneficial owner of such securities
for purposes of Section 13 or for any other purpose.




                                        3

Item 1.      Issuer

                (a)      Alexion Pharmaceuticals, Inc.
                (b)      25 Science Park
                         New Haven, CT  06511

Item 2.      Persons Filing

                (a)      Name of Persons Filing: Citibank, N.A.
                (b)      Address of Principal Offices:
                         153 East 53rd Street
                         New York, New York  10043
                (c)      Citizenship: New York
                (d)      Title of Class of Securities:  Common Stock
                (e)      CUSIP Number:  015351109

Item         3. If this Statement is filed pursuant to Rules 13d-1(b) or
             13d-2(b), check whether the person filing is a:

                (a)      |_|      Broker or Dealer registered under Section 15
                                  of the Act
                (b)      |X|      Bank as defined in Section 3(a)(6) of the Act
                (c)      |_|      Insurance Company as defined in Section
                                  3(a)(19) of the Act
                (d)      |_|      Investment Company registered under Section 8
                                  of the Investment Company Act
                (e)      |_|      Investment Adviser registered under Section
                                  203 of the Investment Advisers Act of 1940
                (f)      |_|      Employee Benefit Plan, Pension Fund which is
                                  subject to the provisions of the Employee
                                  Retirement Income Security Act of 1974 or
                                  Endowment Fund; see ss. 240.13d-1(b)(1)(ii)(F)
                (g)      |_|      Parent Holding Company, in accordance with ss.
                                  240.13d-1(b)(ii)(G)
                (h)      |_|      Group in accordance with 
                                  ss. 240.13d-1(b)(1)(ii)(G)

Item 4.      Ownership

                (a)      Citibank, N.A.:  417,575;
                (b)      Citibank, N.A.:  3.7%;
                (c)      (i)      -0-;
                         (ii)     Citibank, N.A.:  417,575;
                         (iii)    -0-;
                         (iv)     Citibank, N.A.:  417,575.





                                        4

Item 5.      Ownership of Five Percent or Less of a Class

                This statement is being filed to report that as of the date
                hereof the reporting person has ceased to be the beneficial
                owner of more than five percent of the class of securities. |X|

Item 6.      Ownership of More than Five Percent on Behalf of Another Person

                Not applicable.

Item 7.      Identification and Classification of the Subsidiary Which Acquired 
             the Security Being Reported on by the Parent Holding Company

                Not applicable.

Item 8.      Identification and Classification of Members of the Group

                Not Applicable.

Item 9.      Notice of Dissolution of Group

                Not Applicable.

Item 10.     Certification

                By signing below I certify that, to the best of my knowledge and
                belief, the securities referred to above were not acquired and
                are not held for the purpose of or with the effect of changing
                or influencing the control of the issuer of the securities and
                were not acquired and are not held in connection with or as a
                participant in any transaction having that purpose or effect.





                                        5


                                    SIGNATURE

                   After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

Date:  February 24, 1999


                                        CITIBANK, N.A.



                                        By: /s/ Melissa Tanklefsky
                                            ------------------------------------
                                            Name: Melissa Tanklefsky
                                            Title: Vice President