Press Releases
June 1, 2017 at 4:10 PM EDT

Alexion Announces Additions to Executive Leadership Team

- John Orloff, M.D. Appointed Head of Research and Development -

- Anne-Marie Law Joins as Chief Human Resources Officer -

- Indrani Franchini Joins as Chief Compliance Officer -

NEW HAVEN, Conn.--(BUSINESS WIRE)-- Alexion Pharmaceuticals Inc. (NASDAQ:ALXN) today announced key additions to its executive leadership team effective June 5, 2017. Reporting to Chief Executive Officer, Ludwig Hantson will be: John Orloff, M.D., Executive Vice President, Head of Research & Development, Anne-Marie Law, Executive Vice President, Chief Human Resources Officer, and Indrani Lall Franchini, J.D., Executive Vice President, Chief Compliance Officer.

"I am delighted to welcome John, Anne-Marie, and Indrani to Alexion. Each of these highly talented executives brings deep industry experience and a proven track record in their respective areas of expertise," said Ludwig Hantson, Chief Executive Officer of Alexion. "These experienced leaders join our team of exceptionally skilled and dedicated employees around the world and will be key partners as we build upon Alexion's solid foundation to drive continued growth and deliver long-term value for all of our stakeholders."

John Orloff, M.D., Head of Research & Development

Dr. Orloff is a global R&D business leader with 20 years of experience in the biopharmaceutical industry and deep expertise spanning various stages of clinical and non-clinical development, including developing medicines for rare diseases. As Alexion's Head of R&D, Dr. Orloff will be focused on strengthening the Company's clinical pipeline and research programs, enhancing R&D productivity, overseeing regulatory and medical affairs, and supporting business development. Dr. Martin Mackay, Alexion's current Head of R&D, will work with Dr. Orloff to ensure a smooth transition of Alexion's key pipeline programs, including the registration filings of Soliris® (eculizumab) for patients with refractory generalized myasthenia gravis (gMG) and the ALXN1210 clinical development programs.

"John's experience in successfully developing biopharmaceuticals, including in the areas of hematology, immunology, and metabolics, as well his strong global clinical and regulatory expertise, makes him ideally suited to lead the R&D function at Alexion. John and I are aligned on the highest priority development programs, including the gMG registration filings and the ALXN1210 development programs. I'm pleased to work with John again and know him as a leader who fosters effective teams and drives innovation on a global scale to serve the needs of patients," said Dr. Hantson.

Dr. Orloff joins Alexion from Novelion where he served as Executive Vice President, Head of Research & Development since November 2016. Previously, he was Global Head of R&D and Chief Scientific Officer at Baxalta, where he advanced the company's pipeline and oversaw regulatory approval of 10 unique products and two devices over two years. He also held executive R&D roles with Baxter International, Merck Serono, Novartis and Merck Research Laboratories. Prior to joining the biopharmaceutical industry in 1997, Dr. Orloff was with Yale University School of Medicine for seven years. He received his A.B. from Dartmouth College and his M.D. from the University of Vermont College of Medicine, and he completed his medical training at the University of Pittsburgh Medical Center and Yale University School of Medicine.

Anne-Marie Law, Chief Human Resources Officer

Ms. Law is a human resources executive with more than 25 years of experience at global corporations with a strong track record of driving positive change and managing multi-national workforces in multiple global locations. As Alexion's Chief Human Resources Officer, she will be focused on building the organizational capabilities to advance Alexion's strategy.

Dr. Hantson stated, "I am very pleased to once again be partnering with Anne-Marie. She brings to Alexion a strong track record of driving positive change at global corporations and is recognized for delivering high-performance, purpose-driven organizations by building diverse, inclusive, and aligned teams."

Ms. Law joins Alexion from Hyatt Hotels Corporation where she served as Chief Human Resources Officer responsible for building the strategy to support the company's 100,000 employees worldwide, and designing talent systems to create world class leadership and customer connectivity capabilities. Before joining Hyatt in 2016, Ms. Law served as Executive Vice President and Head of Human Resources for Baxalta Incorporated, and held various senior human resources positions at McKesson Corporation, including the Specialty Health Division, VeriSign, and Xilinx, Inc. Ms. Law is a graduate of Leicester University with a degree in Art History in the United Kingdom and The National College of Ireland, Dublin.

Indrani Lall Franchini, J.D., Chief Compliance Officer

Ms. Franchini has extensive experience developing and building the infrastructure and company-wide standards for global compliance programs, interacting with regulatory agencies and establishing multi-functional teams to support global compliance programs. As Alexion's Chief Compliance Officer, Ms. Franchini will be focused on enhancing Alexion's global compliance program, ensuring it meets all legal and regulatory requirements and industry guidelines while protecting the value the Company brings to patients, the community, and external stakeholders. She will also co-lead the Company's newly formed Global Corporate Compliance Committee.

"As we continue to grow worldwide to best serve patients, our commitment to compliance and performing with integrity has never been greater. Given that compliance and growth go hand-in-hand, Indrani, with her global biopharmaceutical experience and by partnering with colleagues across the Company, will ensure that everywhere we do business not only complies with applicable laws and regulations but also meets Alexion's high ethical standards," commented Dr. Hantson.

Ms. Franchini joins Alexion from Hess Corporation where she served as Chief Compliance Officer. Before joining Hess in 2012, Ms. Franchini spent nearly ten years with Pfizer, most recently as Chief Compliance Counsel for its Pharmaceutical Business, overseeing all compliance elements for the development, marketing, and promotion of this global business. Earlier in her career, Ms. Franchini served as an attorney with Milbank, Tweed, Hadley & McCloy in the firm's New York and Tokyo offices. Ms. Franchini earned her J.D. from the University of Michigan Law School and her B.A. from Princeton University. In addition, she spent a year as a Fulbright Fellow at the Kyushu University Graduate School in Fukuoka, Japan.

About Alexion

Alexion is a global biopharmaceutical company focused on developing and delivering life-transforming therapies for patients with devastating and rare disorders. Alexion is the global leader in complement inhibition and has developed and commercializes the first and only approved complement inhibitor to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), two life-threatening ultra-rare disorders. In addition, Alexion's metabolic franchise includes two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare disorders, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D). Alexion is advancing its rare disease pipeline with highly innovative product candidates in multiple therapeutic areas. This press release and further information about Alexion can be found at:


Forward-Looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These forward-looking statements often include words such as "anticipate," "believe," "expect," "will," or similar expressions. Forward-looking statements are subject to factors that may cause Alexion's results and plans to differ from those expected, including for example, risks related to potential disruptions to our business as a result of leadership changes, and a variety of other risks set forth from time to time in Alexion's filings with the U.S. Securities and Exchange Commission, including but not limited to the risks discussed in Alexion's Quarterly Report on Form 10-Q for the period ended March 31, 2017 and in our other filings with the U.S. Securities and Exchange Commission. Alexion does not intend to update any of these forward-looking statements to reflect events or circumstances after the date hereof, except when a duty arises under law.

Alexion Pharmaceuticals Inc.
Kim Diamond, 475-230-3775
Executive Director, Corporate Communications
Elena Ridloff, CFA, 475-230-3601
Vice President, Investor Relations
Catherine Hu, 475-230-3599
Director, Investor Relations

Source: Alexion Pharmaceuticals Inc.

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